Ushering in a new era of medical imaging
New horizons for molecular imaging
Molecular imaging relies on administration of compounds (radiopharmaceuticals) that emit radiation in order to image biological function in vivo.
These radiopharmaceuticals contain a radioactive isotope, most frequently fluorine-18 in the case of PET, that decays and generates radiation detectable by a scanner.
Our patented fluorine-18 radiolabelling method enables the ultra-efficient production of fluorine-18 containing HetSiFA™ compositions for PET scans.
These HetSiFA™ radiopharmaceutical compositions contain a novel class of stabilized Si–F bond that result in superior radiolabeling characteristics.
Catalyze a better diagnostic
We can efficiently attach fluorine-18 to bioactive materials.
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| Comparison Factors | Standard 18F Moiety |
|---|---|
| Bond type/strategy | C-F bond |
| Manufacturing | Challenging; often impractical for large and/or complex molecules |
| Literature | Many reports |
| Radiolabeling time | Typically >20 min |
| Radiosynthesis time | Typically 1-3 hours |
| Radiochemical yield | Highly variable (often <50%); acknowledged reproducibility issues |
| HPLC purification? | Yes |
| Metals required for synthesis? | Typically |
| Personnel | Generally trained chemists |
| Synthesis temperature | up to 150℃ |
| Precursor loading | 15,000-60,000 nmol |
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| Comparison Factors | Fuzionaire Dx HetSiFAs™ |
|---|---|
| Bond type/strategy | C-Si-F bond |
| Manufacturing | Facile using Fuzionaire alkali metal catalysis |
| Literature | Novel compositions and methods; patents granted and pending |
| Radiolabeling time | Seconds |
| Radiosynthesis time | <10 minutes |
| Radiochemical yield | >90% (facile, highly reproducible) |
| HPLC purification? | No |
| Metals required for synthesis? | No |
| Personnel | Accessible to medical technicians |
| Synthesis temperature | Typically 23℃ |
| Precursor loading | ≤50 nmol |
Based on our core chemistry
These advancements are made possible with Fuzionaire’s core chemistry.
With our roots in a Caltech Nobel Laureate’s lab, we are exploring and developing the breakthrough in alkali metal catalysis featured in the film Element 19.
This breakthrough enables a new branch of catalysis that is based on Earth-abundant metals like potassium and sodium.
Read MoreUnlocking the periodic table
Efficient
Earth-abundant metals like potassium and sodium are approximately 25,000,000x more abundant than precious metals.
Cost-effective
The way in which we make and break bonds can be 10,000x less expensive than other methods.
Powerful
Our chemistry enables entirely novel processes that are unlocking new possibilities in molecular science.
Get in touch
If you are interested in learning more about our radiolabeling platform, we want to hear from you.
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